Description

Associate Director, Biochemistry, Proteomics 

Location: Cambridge, MA

How will your role help us transform hope into reality?

We are seeking an accomplished and driven proteomics scientist to join our team at the Associate Director level. The ideal candidate is an expert in quantitative proteomics with a solid background in mass spectrometry research and a proven track record in advancing drug discovery projects through proteomics. In this role, you will leverage your expertise to drive innovation in proteomics capabilities and strengthening our targeted protein degradation platform. Working closely with computational biology experts, you’ll enhance informatics workflows for comprehensive data capture, analysis, and archiving, enabling in-depth and cross-study analysis.

Desirable experience includes both global and targeted proteomics studies on the ubiquitin-proteasome pathway, characterization of PROTACs or molecular glue degraders, and protein interactome analysis. Experience in ubiquitinomics, affinity- or crosslinking techniques, or proximity labeling-based chemical proteomics is also highly desirable

What will you do?

• As part of the proteomics team you will identify, evaluate, and implement latest technologies and expand internal proteomics capabilities, in alignment with discovery project needs.
• Collaborate with the computational biology team to optimize workflows for data management and in-depth analysis.
• Design, execute, and interpret experiments that address key challenges in our drug discovery initiatives. 
• Perform data analysis, share results, and present findings to project and department teams, providing insights and recommendations. 
• Explain relevant methodologies, applications, and limitations effectively to colleagues from other scientific disciplines. 
• Develop strategies to deepen proteomics integration into drug discovery, enhancing both precision and throughput, taking innovative approaches to address evolving challenges.
• Potential to lead the proteomics team based on people management experience.

What minimum qualifications do we require? 

• Ph.D. in Biochemistry, Chemical Biology, Analytical Chemistry, or a related field with 5+ years of post-graduate experience, or an M.S. degree with 8+ years of research experience.
   

What additional qualifications will make you a stronger candidate? 

• Proteomics Expertise: Solid understanding of proteomics methodologies, including labeled and label-free quantification techniques and post-translational modifications, such as ubiquitination. Hands-on experience in setting up, operating, developing methods, and troubleshooting liquid chromatography and mass spectrometry systems from various instrument vendors. Skilled in sample preparation, data acquisition, and analysis, with proficiency in latest proteomics data analysis software. Experience in targeted protein degradation or ubiquitin-proteasome system biology highly desirable.
• Additional Laboratory Skills: Practical knowledge of cell culture, affinity pull-down or other chemical biology methods preferred but not required. Experience in sample handling automation a plus.
• Drug Discovery Experience: Good understanding of, and passion for the drug discovery process.
• Commitment to Blueprint Medicines’ Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism
   

Why Blueprint?

At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators – the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

This is the place where the extraordinary becomes reality, and you could be part of it. 

Patients are waiting. Are you ready to make the leap?

Equity, Diversity, Inclusion and Affirmative Action

At Blueprint Medicines, we foster a culture of equity, diversity and inclusion.  A proud Equal Employment Opportunity and Affirmative Action employer, we consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.  We are also an E-Verify Employer.  We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of an accommodation with the application or recruiting process, please reach out to TotalRewards@blueprintmedicines.com.  

For more information, please see our EEO-AA Policy Statement, the EEO Know Your Rights Poster, as well as our Pay Transparency Statement.  

Blueprint Medicines is a fully integrated, commercial-stage, global biopharmaceutical company that invents life-changing medicines in two core, strategic areas of allergy/inflammation and oncology/hematology. We pursue discovery, development, and commercialization of therapies that potently and selectively target known drivers of disease, with focused investment in therapeutic areas where we can leverage our core expertise and business infrastructure to bring scale to our science. We are bringing an approved medicine to people living with systemic mastocytosis (SM) in the U.S. and Europe. Additionally, we have a pipeline of research and development programs that range from early science to advanced clinical trials in mast cell-mediated diseases, including SM and chronic urticaria, breast cancer, and other solid tumors vulnerable to CDK2 inhibition.